| HAN Junqing,WANG Xingwen,WANG Yu,et al.A clinical prospective study of radiosensitization on lung adenocarcinoma by agrimophol[J].Chinese Journal of Radiological Medicine and Protection,2003,23(5):355-357 |
| A clinical prospective study of radiosensitization on lung adenocarcinoma by agrimophol |
| Received:March 26, 2003 |
| DOI： |
| KeyWords:Agrimophol Lung adenocarcinoma Radiosensitization |
| FundProject: |
| Author Name | Affiliation | | HAN Junqing | Cancer Medicine Center, Shandong Provincial Hospital, Jinan 250021, China | | WANG Xingwen | Cancer Medicine Center, Shandong Provincial Hospital, Jinan 250021, China | | WANG Yu | Cancer Medicine Center, Shandong Provincial Hospital, Jinan 250021, China | | 李冠贞 | Cancer Medicine Center, Shandong Provincial Hospital, Jinan 250021, China | | 韩玉萍 | Cancer Medicine Center, Shandong Provincial Hospital, Jinan 250021, China | | 杨哲 | Cancer Medicine Center, Shandong Provincial Hospital, Jinan 250021, China | | 颜廷秀 | Cancer Medicine Center, Shandong Provincial Hospital, Jinan 250021, China | | 洪士强 | Cancer Medicine Center, Shandong Provincial Hospital, Jinan 250021, China |
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| Abstract:: |
| Objective To explore the curative effect of radiosensitization by agrimophol through a clinical prospective study on lung adenocarcinoma treated by radiotherapy. Methods A total of 122 patients with lung adenocarinoma were divided into two groups randomly by double blind method:the radiosensitization group (given agrimophol orally, BID )and the control group(given placebo). Curative effects were observed in these two groups treated using the same foundational factors and treatment conditions in the course of radiotherapy. Results The CR rate of tumor increased by 41.4% in the radiosensitization group compared with the control group at the end of radiotherapy. The 1-, 3-,and 5-year survival rate of the radiosensitization group increased by 23.2%, 17.2% and 12.7%,respectively, compared with that of the control group after radiotherapy. There were no statistic differences in radiopneumonitis incidence and tumor distant metastasis rate between these two groups. The incidence of pleural fluid and the relapse rate of tumor in the radiosensitization group were significantly lower than that of the control group. Conclusions Agrimophol can significantly exert radiosensitization effect on lung adenocarcinoma cells, but does not affect development of radiopneumonitis and tumor distant metastasis. At the same time,agrimophol can significantly reduce the incidence of pleural fliud and tumor relapse after radiotherapy. |
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