| CHENG Guanghui,JIANG Defu,WANG Tiejun.A randomized prospective study on combined treatment of patients with stage-Ⅲ breast cancer[J].Chinese Journal of Radiological Medicine and Protection,2003,23(5):346-348 |
| A randomized prospective study on combined treatment of patients with stage-Ⅲ breast cancer |
| Received:September 15, 2002 |
| DOI： |
| KeyWords:Breast neoplasms Surgery Radiotherapy Chemotherapy |
| FundProject: |
| Author Name | Affiliation | | CHENG Guanghui | Department of Radiation Oncology, Second Hospital of Jilin University, Changchun 130021, China | | JIANG Defu | Department of Radiation Oncology, Second Hospital of Jilin University, Changchun 130021, China | | WANG Tiejun | Department of Radiation Oncology, Second Hospital of Jilin University, Changchun 130021, China | | 曲雅琴 | Department of Radiation Oncology, Second Hospital of Jilin University, Changchun 130021, China | | 吴镇凤 | Department of Radiation Oncology, Second Hospital of Jilin University, Changchun 130021, China | | 韩冬梅 | Department of Radiation Oncology, Second Hospital of Jilin University, Changchun 130021, China |
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| Abstract:: |
| Objective To evaluate the curative effect of three different kinds of treatment for patients with stage-Ⅲ breast cancer. Methods Eighty patients with stage-Ⅲ breast cancer were randomized into three different groups:28 were treated by preoperative chemotherapy,combined with surgery and radiotherapy (group A);28 by surgery combined with chemotherapy and radiotherapy (group B);and 29 by surgery combined with radiotherapy and chemotherapy (group C).Differences in local regional recurrence,distant metastasis and 5-year survival rate were analysed for the three groups. Results The five-year survival rates were 57.65%,75.00%,53.57%,44.83% for the whole series and groups A,B,C,respectively.The difference was statistically significant between groups A and C (P<0.05).The local regional recurrence rates were 18.82%,7.14%,32.14%,17.24% for the whole series and groups A,B,C,respectively.The difference was statistically significant between groups A and B (P<0.05).The distant metastasis rates were 18.82%,7.14%,10.71%,37.93% for the whole series and groups A,B,C,respectively.The difference was statistically significant between groups A or B and C(P<0.05). Conclusion Preoperative chemotherapy plus surgery and followed by radiotherapy may improve the outcome of stage-Ⅲ breast cancer. |
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