| SUN Suping,CAI Jianming,XIANG Yingsong.Experimental study on homing of bone marrow cells after scheduled transplatation in allogeneic mice[J].Chinese Journal of Radiological Medicine and Protection,2003,23(5):327-329 |
| Experimental study on homing of bone marrow cells after scheduled transplatation in allogeneic mice |
| Received:January 12, 2003 |
| DOI： |
| KeyWords:Allogeneic mouse Scheduled transplantation Homing |
| FundProject:国家自然科学基金资助项目(39770329,39600077) |
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| Abstract:: |
| Objective To investigate the effects of transplantation times and number of transplanted cells on homing of these cells after scheduled bone marrow transplantation. Methods An allogeneic mouse model and flow cytometric detection were used to observe homing efficacy of transplantation times and number of cells transplanted. Results After different times of scheduled transplantation,the highest number of homing cells and homing efficiency were both observed after the third time of transplantation in every group,and detecting at same time point (the fourth day) showed that the highest results was obtained in the transplanted group ( P< 0.05),suggesting that there might be different homing patterns after d ifferent times of transplantation.After the scheduled transplantation of different number of cells,the number of homing cells of low cell number group was not diffent from that of high number group,but the homing efficiency was higher than the latter ( P< 0.01),suggesting that the homing efficacy of multi-transplantation with low cell number may be equal or superior to that of a single injection of a large number of cells and the accumulated number of cells may be reduced to 105. Conclusion The routine method of transplanting a large number of cells by a single injection may be waste of the stem cells.In a certain range of cell number,transplantation efficiency may be enhanced by changes of transplantation schedule. |
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