| CHEN Honghong,HU Yuxing,WANG Yinghua.Protective effect of chelating agents of catechols amino carboxylic acid on radiation injury induced by radiothorium in mice:prompt administration[J].Chinese Journal of Radiological Medicine and Protection,2003,23(5):320-323 |
| Protective effect of chelating agents of catechols amino carboxylic acid on radiation injury induced by radiothorium in mice:prompt administration |
| Received:September 08, 2002 |
| DOI： |
| KeyWords:Chelating agent Thorium-234 Internal radiation injury Lipid peroxidation Decorporation |
| FundProject:国家自然科学基金青年基金资助项目(39700039) |
| Author Name | Affiliation | | CHEN Honghong | Institute of Radiation Medicine, Fudan University, Shanghai 200032, China | | HU Yuxing | Institute of Radiation Medicine, Fudan University, Shanghai 200032, China | | WANG Yinghua | Institute of Radiation Medicine, Fudan University, Shanghai 200032, China | | 金美英 | Institute of Radiation Medicine, Fudan University, Shanghai 200032, China | | 罗梅初 | Institute of Radiation Medicine, Fudan University, Shanghai 200032, China | | 孙梅贞 | Institute of Radiation Medicine, Fudan University, Shanghai 200032, China |
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| Abstract:: |
| Objective To study decorporation and antioxidation efficacy of chelating agents (9501 and 7601) of the substituted catechols amino carboxylic acid for radiothorium in vivo. Methods The experiment was first designed to find out the dose and time of radiation injury by incorporated 234Th-citrate in ICR mice.The malondialdehyde (MDA) production serving as an index of 234Th-induced lipid peroxidation in bone marrow,serum and liver of mice was assayed and the numbers of bone marrow nucleated cells (NBMNC) were counted.The pathological changes of bone marrow and liver tissue were observed.The chelating agents were promptly administered im to mice for three consecutive days after ip injection of 0.6 MBq 234Th-citrate.The animals were sacrificed 4 days later and the 234Th retention in the whole body,liver and skeleton and the above indexes were determined. Results The mice showed significantly internal radiation injury of bone marrow and liver at 4th to 8th after ip injection of 0.6 MBq 234Th-citrate.The prompt administration of 9501,7601 and DTPA decreased the whole body radioactivity by 81%,86% and 72%,respectively,as compared with those of the control group.The sum of retention of 234Th in liver and skeleton was reduced to 22%,21% and 58% of controls,respectively.The removal efficacy of 9501 and 7601 was better than that of DTPA.The NBMNC,contents of MDA in bone marrow and the structure of bone marrow and liver tissue didn't show any abnormality in 9501 and 7601 groups.DTPA appeared to have a lower protective effectiveness on radiation injury of bone marrow.VitE had no decorporation activity and didn't alleviate radiotoxicity.The combined use of DTPA and VitE showed both decorporation effect of DTPA and antioxidation effect of VitE. Conclusion The prompt administration of 9501 and 7601 has remarkable protective effects on internal radiation injury,which resulting from decorporation activity and conceal their antioxidation. |
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