| YUE Lu,GUI Lü,CHEN Honghong,et al.Research on the inhibitory effect of interstitial brachytherapy with 125I seeds in treatment of solid tumors in mice[J].Chinese Journal of Radiological Medicine and Protection,2003,23(5):314-316 |
| Research on the inhibitory effect of interstitial brachytherapy with 125I seeds in treatment of solid tumors in mice |
| Received:December 15, 2002 |
| DOI： |
| KeyWords:125I seeds Interstitial brachytherapy Ehrlich ascite tumor cells |
| FundProject:上海市科技发展基金资助项目(994119002) |
| Author Name | Affiliation | | YUE Lu | Institute of Radiation Medicine, Fudan University, Shanghai 200032, China | | GUI Lü | 200032 上海, 复旦大学附属金山医院病理科 | | CHEN Honghong | Institute of Radiation Medicine, Fudan University, Shanghai 200032, China | | 罗伟华 | Institute of Radiation Medicine, Fudan University, Shanghai 200032, China | | 徐萍 | Institute of Radiation Medicine, Fudan University, Shanghai 200032, China | | 刘伟琪 | Institute of Radiation Medicine, Fudan University, Shanghai 200032, China | | 程文英 | Institute of Radiation Medicine, Fudan University, Shanghai 200032, China |
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| Abstract:: |
| Objective To study the inhibitory effect of interstitial brachytherapy with 125I seeds in treatment of solid tumors in mice. Methods Solid tumor-bearing mice were produced with Ehrlich ascites tumor cells (EAC) and were divided into a treatment group (n=12) and a control group (n=10). In each mouse of the treatment group, four BT-125-Ⅰ Model 125I seeds with apparent activity of 8.14 MBq were implanted into the tumor; whereas in each mouse of the control group four dummy seeds were implanted. The mice survival rates of both groups were recorded after 28 days. The tumor weights and dimensions of survived mice were measured; tumor volume inhibition rate was calculated. T-test was performed to compare differences of tumor weights and volumes between these two groups. Routine pathological slides of tumor tissue were observed under light microscope to evaluate the range of tumor tissues damaged by 125I seeds. Results The survival rate of the treatment group was 75% and that of control group was 50%; the average weights of tumors of these two groups were (0.347±0.249)g and (5.162±1.749)g, respectively( t=6.164,P<0.05); and the average volumes of tumors were (175.9±147.9)mm3 and (3974.1±1507.7)mm3, respectively( t=5.618,P<0.05). The tumor volume inhibition rate was 95.6%. Pathological examination showed coagulative necrosis and degenerative necrosis dramatically presented at the range of 1 mm to 3 mm distance to active 125I seeds. No pathological changes but slight edema and fibroplasia were observed at the periphery of dummy seeds. Conclusion The visible effective radius of 125I seeds used in this study was about 3 mm on pathological slides of tumor tissue. The interstitial brachytherapy with 125I seeds could significantly inhibit the growth of EAC solid tumor of mice. |
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