| XING Yigang,TANG Yamei,SUN Ying.Development of a murine model of acute radiation encephalopathy[J].Chinese Journal of Radiological Medicine and Protection,2003,23(4):269-270 |
| Development of a murine model of acute radiation encephalopathy |
| Received:January 31, 2003 |
| DOI： |
| KeyWords:Radiation injury Animal mode Brain |
| FundProject: |
| Author Name | Affiliation | | XING Yigang | Department of Neurology, The Second Affiliated Hospital of Sun Yat-sen University, Guangzhou 510120, China | | TANG Yamei | Department of Neurology, The Second Affiliated Hospital of Sun Yat-sen University, Guangzhou 510120, China | | SUN Ying | 510120 广州, 中山大学附属肿瘤医院放疗科 | | 刘军 | Department of Neurology, The Second Affiliated Hospital of Sun Yat-sen University, Guangzhou 510120, China |
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| Abstract:: |
| Objective To develop a murine model of acute radiation encephalopathy. Methods A total of 40 rats were subjected to local γ-irradiation to the brain with the dosage of 7 Gy/d for 6 consecutive days.The amoute of food intake, hairs and skin of irradiated field, body weight, general activities, CNS symptoms and signs were examined and recorded after irradiation.On day 3, 7, 14 and 30, the brain tissue was removed to observe histopathologic changes. Results During the first two days after irradiation, the irradiated rats were agitated, and the amount of food intake decreased from day 2 onwards.No serious skin reaciton to irradiation was observed.Survived rats had normal activities without any abnormal nervous signs.Histopathologic changes showed slight neuronal degeneration, smaller cell body, red-colored cytoplasm, disappearance of Nissl body, vacuolation, typical cell shrinkage, chromatin condensation and nuclear divergence.On the 14th and 30th days, hypochromatism, loose and reticular necrotic foci were found in some samples. Conclusion Our murine model of acute radiation encephalopathy is useful and practical in radiobiologic studies. |
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