| QU Shuang,ZHANG Sa,CHEN Ying.Structural analysis of γ radiation-induced chromosomal aberrations observed by atomic force microscopy[J].Chinese Journal of Radiological Medicine and Protection,2003,23(4):263-264 |
| Structural analysis of γ radiation-induced chromosomal aberrations observed by atomic force microscopy |
| Received:November 15, 2002 |
| DOI： |
| KeyWords:Radiation Chromosome structure Atomic force microscopy |
| FundProject: |
| Author Name | Affiliation | E-mail | | QU Shuang | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | yingchen29@yahoo.com.cn | | ZHANG Sa | 100850 北京, 军事医学科学院仪器测试分析中心 | | | CHEN Ying | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | | 葛世丽 | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | | 刘秀林 | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | | 张德添 | 100850 北京, 军事医学科学院仪器测试分析中心 | | | 周平坤 | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | |
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| Abstract:: |
| Objective To find a new method for the measurement of radiation-induced damage, the structures of normal chromosomes and 60Coγ-ray-induced chromosomal aberration were analyzed by atomic force microscopy. Methods Normal and irradiated chromosomes of human peripheral blood lymphocytes were prepared, then three-dimensional structure and height of chromosomes were analyzed by atomic force microscopy. Results Three-dimensional structures of normal chromosomes and dicentric aberration in irradiated chromosomes were observed clearly. The data of chromosome height were helpful to recognizing the dicentric aberrations. Conclusion Atomic force microscopy providing three-dimension image and linear measurement is a new and valuable tool for structural analysis of radiation-induced chromosomal aberrations. |
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