| BAI Yushu,HUANG Qilong,MA Jianfeng,et al.A comparative study on biological effectiveness of chromosomal aberrations induced by heavy ion versus 60Co γ-rays in human peripheral blood lymphocytes[J].Chinese Journal of Radiological Medicine and Protection,2003,23(4):258-260 |
| A comparative study on biological effectiveness of chromosomal aberrations induced by heavy ion versus 60Co γ-rays in human peripheral blood lymphocytes |
| Received:December 10, 2002 |
| DOI： |
| KeyWords:Heavy ion Human blood in vitro Dose-respond curve Relative biological effectiveness |
| FundProject: |
| Author Name | Affiliation | E-mail | | BAI Yushu | National Institute for Radiological Protection and Nuclear Safety, China CDC, Beijing 100088, China | suxu@163bj.com | | HUANG Qilong | National Institute for Radiological Protection and Nuclear Safety, China CDC, Beijing 100088, China | | | MA Jianfeng | National Institute for Radiological Protection and Nuclear Safety, China CDC, Beijing 100088, China | | | 关树荣 | National Institute for Radiological Protection and Nuclear Safety, China CDC, Beijing 100088, China | | | 雷苏文 | National Institute for Radiological Protection and Nuclear Safety, China CDC, Beijing 100088, China | | | 李文建 | 中国科学院近代物理研究所 | | | 苏旭 | National Institute for Radiological Protection and Nuclear Safety, China CDC, Beijing 100088, China | |
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| Abstract:: |
| Objective To compare the effectiveness of heavy ion versus 60Coγ-rays in producing chromosomal aberrations in human lymphocytes. Methods Heparinized whole blood samples were exposed to heavy ion 12C and 60Coγ-rays, respectively.Unstable chromosomal aberrations including acentric fragments, minutes, acentric rings, dicentrics and centric rings(“dic+r”) were scored.Relative biological effectiveness (RBE) values of “dic+r” were derived. Results Chromosomal aberrations (“dic+r”) induced by either heavy ion 12C or 60Coγ-rays had a good dose-response relationship.Their best fitiing regression equations were PY=0.858503D+0.36154×10-2D2 (PR=0.9840) and PY=0.269792D+7.73083×10-2D2 (PR=0.9920), respectively.RBE values of heavy ion at 0.3-8.0 Gy ranged from 2.62 to 1.0, with an average of 1.58. Conclusion Heavy ion 12C has higher biological effectiveness in inducing chromosomal aberrations. |
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