| HE Guijin,ZHANG Shengzhong,JING Yongbai,et al.Radiation injury of canine bile duct induced by 103Pd metal stent[J].Chinese Journal of Radiological Medicine and Protection,2003,23(3):178-179 |
| Radiation injury of canine bile duct induced by 103Pd metal stent |
| Received:October 31, 2002 |
| DOI： |
| KeyWords:Bile duct Radiation effects Pathology Brachytherapy |
| FundProject: |
| Author Name | Affiliation | | HE Guijin | Department of General Surgery, Second Clinical College, China Medical University, Shenyang 110004, China | | ZHANG Shengzhong | 沈阳第十人民医院普外科 | | JING Yongbai | 中国科学院沈阳金属研究所 | | 曹明洲 | 中国科学院沈阳金属研究所 | | 姜维国 | 110004 沈阳, 中国医科大学第二临床学院病理科 | | 戴显伟 | Department of General Surgery, Second Clinical College, China Medical University, Shenyang 110004, China | | 高红 | 110004 沈阳, 中国医科大学第二临床学院儿外实验室 | | 蒋涛 | 110004 沈阳, 中国医科大学第二临床学院儿外实验室 | | 马凯 | Department of General Surgery, Second Clinical College, China Medical University, Shenyang 110004, China |
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| Abstract:: |
| Objective To assess radiation injury of dog bile duct induced by 103Pd metal stent. Methods Hybrid dogs with body weight form 15 to 20 kg were used. 103Pd metal stent was implanted into the common bile duct under anaesthesia, and the irradiation doses by 103Pd were 12.5×104kBq, 16.6×104kBq, 22.2×104kBq, 25. 9×104kBq, 29.6×104kBq and 3.7×105kBq, respectively. Results Radiation injury on the mucosa of the bili duct was observed in 12.5×104kBq group, and the damage extended to the muscular layer in 22.2×104kBq group.Perforation of the bile duct was observed in 3.7×105kBq group.The dose-response curve of radiation injury at different doses of intra-biliary metal stent 103Pd showed the effective dose (ED50) to be 28.2×104kBq. Conclusion There is an obvious dose response relationship for in the 103Pd metal stent.our result is unimportant theoretical basis for application of 103Pd metal stent to clinical treatment of biliary cancer. |
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