| SUN Suping,CAI Jianming,XIANG Yingsong.Evidence of homing of each fraction of bone marrow cells after scheduled transplatation in mice[J].Chinese Journal of Radiological Medicine and Protection,2003,23(3):157-159 |
| Evidence of homing of each fraction of bone marrow cells after scheduled transplatation in mice |
| Received:August 21, 2002 |
| DOI： |
| KeyWords:Scheduled bone marrow transplantation Homing Niche |
| FundProject:国家自然科学基金资助项目(39770329,39600077) |
| Author Name | Affiliation | | SUN Suping | Department of Radiation Medicine, Second Military Medical University, Shanghai 200433, China | | CAI Jianming | Department of Radiation Medicine, Second Military Medical University, Shanghai 200433, China | | XIANG Yingsong | Department of Radiation Medicine, Second Military Medical University, Shanghai 200433, China | | 黄定德 | Department of Radiation Medicine, Second Military Medical University, Shanghai 200433, China | | 赵芳 | Department of Radiation Medicine, Second Military Medical University, Shanghai 200433, China | | 高建国 | Department of Radiation Medicine, Second Military Medical University, Shanghai 200433, China | | 杨如俊 | Department of Radiation Medicine, Second Military Medical University, Shanghai 200433, China |
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| Abstract:: |
| Objective To identify homing of bone marrow cells after every fractionation during scheduled transplantation. Methods The recipient mice were transplanted with homologous (H-2Kd) and allogenic(H-2Kb) mouse bone marrow cells after lethal irradiation, and the homing status of allogenic bone marrow cells in host bone marrow and spleen was observed. Results A quantity of allogenic homed cells were observed in host bone marrow, and the percentage of homing cells in second fraction was the highest in all groups (P<0.01).The allogenic homed cells in spleen declined along with increase of the number of fraction, suggesting that regulation of homing to spleen was different from that to bone marrow. Conclusion In scheduled bone marrow transplantation niche may be more effectively utilized and thus transplation efficiency be enhanced. |
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