| LEI Suwen,SU Xu,BAI Yushu.A comparative study on micronuclei production induced by carbon ion versus 60Coγ-rays in human peripheral blood lymphocytes[J].Chinese Journal of Radiological Medicine and Protection,2003,23(3):151-153 |
| A comparative study on micronuclei production induced by carbon ion versus 60Coγ-rays in human peripheral blood lymphocytes |
| Received:August 28, 2002 |
| DOI： |
| KeyWords:Carbon ion 60Coγ-rays CB micronucleus method Relative biological effecitiveness |
| FundProject:国家自然科学基金资助项目(10105012) |
| Author Name | Affiliation | | LEI Suwen | National Institute for Radiological Protection and Nuclear Safety, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | SU Xu | National Institute for Radiological Protection and Nuclear Safety, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | BAI Yushu | National Institute for Radiological Protection and Nuclear Safety, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | 王菊芳 | 中国科学院近代物理研究所 | | 马剑锋 | National Institute for Radiological Protection and Nuclear Safety, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | 黄绮龙 | National Institute for Radiological Protection and Nuclear Safety, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | 关树荣 | National Institute for Radiological Protection and Nuclear Safety, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | 李文建 | 中国科学院近代物理研究所 |
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| Abstract:: |
| Objective To compare the effectiveness of carbon ion versus 60Co γ rays in producing micronuclei in human peripheral blood lymphocytes. Method Heparinized whole blood samples were exposed to carbon ion and 60Co γ rays, respectively.Micronuclei in binuclear lymphocytes (CB method) were scored.Relative biological effectiveness (RBE) values were caluclated. Results RBE values of carbon ion decreased with increasing dose (ranged from 1.78 to 4.19 Gy).The average RBE value is 2 56. Conclusion Carbon ion has higher biological effectiveness in inducing micronuclei than 60Co γ-rays do. |
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