| LI Xiujuan,LI Xiuyi,TIAN Mei.Expression of pEgr-ssEndostatin in tumor induced by radiation and its anti-tumor effect[J].Chinese Journal of Radiological Medicine and Protection,2003,23(3):148-150 |
| Expression of pEgr-ssEndostatin in tumor induced by radiation and its anti-tumor effect |
| Received:September 10, 2002 |
| DOI： |
| KeyWords:pEgr-ssEndostatin recombinant plasmids Gene-radiotherapy X-ray irradiation B16 melanoma |
| FundProject:国家自然科学基金资助项目(30170290) |
|
| Hits: 2685 |
| Download times: 1851 |
| Abstract:: |
| Objective To observe the antitumor effect of pEgr-ssEndostatin gene-radiotherapy to murine melanoma and the expression of Endostatin gene in tumor induced by radiation. Methods pEgr-ssEndostatin plasmids were injected locally into the tumor in B16 mice, and 42 h later, the tumors of half of the mice were given 20 Gy X-irradiation.The tumor growth at different times and Endostatin expression 2 days after irradiation were detected. Results Endostatin gene-radiotherapy could enhance the curative effect of radiotherapy.Both pEgr-ssEndostatin group and pEgr-ssEndostatin+20 Gy group had Endostatin mRNA expression, but the mRNA level of pEgr-ssEndostatin+20 Gy group was higher than that of pEgr-ssEndostatin group. Conclusion The antitumor effect of pEgr-ssEndostatin gene-radiotherapy is better than that of radiotherapy and gene therapy only.And Endostatin expression in tumor is enhanced after irradiation. |
| HTML View Full Text View/Add Comment Download reader |
| Close |
