| ZHANG Tong,XU Zhishun,WEI Wei,et al.Study of radionuclide 90Sr-90Y on cell proliferation and apoptosis in benign prostatic hyperplasia[J].Chinese Journal of Radiological Medicine and Protection,2003,23(2):98-99 |
| Study of radionuclide 90Sr-90Y on cell proliferation and apoptosis in benign prostatic hyperplasia |
| Received:May 12, 2002 |
| DOI： |
| KeyWords:90Sr-90Y Benign prostatic hyperplasia Proliferation Apoptosis |
| FundProject: |
| Author Name | Affiliation | | ZHANG Tong | Department of Urology, Shandong Traffic Hospital, Jinan 250031, China | | XU Zhishun | Department of Urology, Shandong Traffic Hospital, Jinan 250031, China | | WEI Wei | Department of Urology, Shandong Traffic Hospital, Jinan 250031, China | | 刘芳 | Department of Urology, Shandong Traffic Hospital, Jinan 250031, China | | 徐祗顺 | 山东大学齐鲁医院 |
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| Abstract:: |
| Objective To investigate the effect of 90Sr-90Y on cell proliferation and apoptosis in benign prostatic hyperplasia. Methods The apoptosis and expression of Ki-67 in benign prostatic hyperplasia (BPH) before and after irradiation 90Sr-90Y were detected by transferase-mediated dUTP-biotin nick end labeling (TUNEL) method and immunohistochemical technique, respectively. Results The proliferation index (PI) of BPH after 90Sr-90Y irradiation was much lower than that before irradiation, but there was no significant change in apoptosis index (AI). Conclusion Irradiation with 90Sr-90Y could restrain cell proliferation of BPH, but could not induce apoptosis. |
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