| GU Qing yang,WANG Dewen,YANG Zhixiang,et al.Expression of PDGF-B and PDGFR-β during the formation and development of acute radiation-induced skin ulcers and their effects on ulcer healing:a comparative study with normal wound healing[J].Chinese Journal of Radiological Medicine and Protection,2003,23(2):86-88 |
| Expression of PDGF-B and PDGFR-β during the formation and development of acute radiation-induced skin ulcers and their effects on ulcer healing:a comparative study with normal wound healing |
| Received:May 11, 2002 |
| DOI： |
| KeyWords:Radiation-induced skin ulcder PDGF-B PDGFR -β Wound healing |
| FundProject:全军“九·五”医药卫生科研基金课题(96Q036) |
| Author Name | Affiliation | | GU Qing yang | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | WANG Dewen | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | YANG Zhixiang | 军事医学科学院附属医院 | | 王晓民 | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | 高亚兵 | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | 杨红 | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | 刘杰 | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | 赵梅兰 | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | 崔玉芳 | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | 崔雪梅 | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China |
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| Abstract:: |
| Objective To study the expression of PDGF-B and PDGFR-β during the formation and development of radiation-induced skin ulcers and their effects on ulcer healing. Methods A rat model which was locally irradiated with 60Co γ-rays was used, and another rat model of surgical skin wounds was made.Pathological changes were observed for 55 days.Immunohistochemistry, in situ hybridization and image analysis were performed to detect PDGF-B and PDGFR-β expression in the tissue of radiation skin ulcers and surgical wounds. Results Skin ulcers were found on day 14 after irradiation, and they were enlarged and deepened gradually during the observation period.In the irradiated skin, especially in the epidermal cells, fibroblasts and endothelial cells of the ulcer beds, the expressions of PDGF-B and PDGFR-β were higher than those in normal skin.But their expression were obviously decreased in the radiation ulcer beds compared to those in the surgical wound beds. Conclusion After irradiation, the decreased expressions of PDGF-B and PDGFR-β may play an important role in the formation, development and nonhealing mechanism of radiation skin ulcers. |
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