| LEI Suwen,Su Xu,WANG Jufang,et al.Clonogenic cell line survival of a human liver cancer cell line SMMC-7721 after carbon ion irradiation with different LET[J].Chinese Journal of Radiological Medicine and Protection,2003,23(2):83-85 |
| Clonogenic cell line survival of a human liver cancer cell line SMMC-7721 after carbon ion irradiation with different LET |
| Received:March 05, 2002 |
| DOI： |
| KeyWords:LET,Carbon ion Human liver cancer cell line SMMC-7721 Clonogenic cell survival |
| FundProject:国家自然科学基金资助项目(10105012) |
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| Abstract:: |
| Objective To investigate the survival fraction of a human liver cancer cell line SMMC-7721 following irradiation with carbon ions with different LET. Methods cells of the human liver cancer cell line SMMC-7721 were irradiated with carbon ions (LET=30 and 70 keV/μm).The survival fraction was determined with clonogenic assay after 9 days incubation in a 5% CO2= incubator at 37℃. Results The survival fractions of 70 keV/μm at Ds=0.1 and Ds=0.01 were 2 .94 and 5.88 Gy, and those of 30 keV/μm were 4 00 and 8.00 Gy at respectively. Conclusion For the SMMC-7721 cell line, 70 keV/μm is more effective for cell killing than 30 keV/μm. |
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