| HUANG Dingde,CHEN Qi,HAN Ling.Study on expression of SH2 domain-containing protein tyrosine phospatase SHP-1 and SHP-2 in γ-ray irradiation -induced thymus lymphoma in mice[J].Chinese Journal of Radiological Medicine and Protection,2003,23(1):23-25 |
| Study on expression of SH2 domain-containing protein tyrosine phospatase SHP-1 and SHP-2 in γ-ray irradiation -induced thymus lymphoma in mice |
| Received:March 04, 2002 |
| DOI： |
| KeyWords:Radiation carcinogenesis Signal transduction Protein tyrosine phosphatase |
| FundProject: |
| Author Name | Affiliation | | HUANG Dingde | Department of Radiation Medicine, the Second Military Medical University, Shanghai 200433, China | | CHEN Qi | Department of Radiation Medicine, the Second Military Medical University, Shanghai 200433, China | | HAN Ling | Department of Radiation Medicine, the Second Military Medical University, Shanghai 200433, China | | 蔡建明 | Department of Radiation Medicine, the Second Military Medical University, Shanghai 200433, China | | 李百龙 | Department of Radiation Medicine, the Second Military Medical University, Shanghai 200433, China | | 黄越承 | Department of Radiation Medicine, the Second Military Medical University, Shanghai 200433, China | | 高建国 | Department of Radiation Medicine, the Second Military Medical University, Shanghai 200433, China | | 孙苏平 | Department of Radiation Medicine, the Second Military Medical University, Shanghai 200433, China |
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| Abstract:: |
| Objective To investigate the expression of SH2 domain containing-protein tyrosine phosphatase SHP-1 and SHP-2 in γ-ray irradiation-induced thymus lymphoma in mice. Methods Altogether 338 BALB/c mice were randomly divided into irradiation groups and controls.Irradiation groups which were irradiated with γ-rays included canceration groups confirmed with histology and uncanceration groups.The controls were fed synchronistically with irradiation groups.The expression of SHP-1 and SHP-2 was detected with Western blot in thymus cells. Results The expression of SHP-1 in canceration groups was much higher than that in uncanceration groups and controls significantly, while the expression of SHP-2 in uncaneration groups was higher than that in uncanceration groups and controls.When we detected the expression of SHP-2 with Western blot, we found another protein with a molecular weight of 55×103, which expression in canceration groups was higer than that in uncanceration groups and controls. Conclusion The expression of SH2 domain-containing protein tyrosine phosphatase SHP-1 and SHP-2 is significantly increased in canceration groups, suggesting that SHP-1 and SHP-2 may be related with γ-ray induced thymus lymphoma in mice.Further research is expected on the relationship between deve-lopment of cancer and SHP-1 and SHP-2. |
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