| LEI Suwen,SU Xu,BAI Yushu,et al.The dose-effect curve of micronuclei established with human peripheral blood lymphocytes after irradiation with heavy ion beams 12C6+[J].Chinese Journal of Radiological Medicine and Protection,2003,23(1):20-22 |
| The dose-effect curve of micronuclei established with human peripheral blood lymphocytes after irradiation with heavy ion beams 12C6+ |
| Received:July 09, 2002 |
| DOI： |
| KeyWords:Heavy ion beams 12C6+ CB micronucleus method Dose-effect curve |
| FundProject:国家自然科学基金资助项目(10105012) |
| Author Name | Affiliation | | LEI Suwen | National Institute for Radiological Protection and Nuclear Safety, China CDC, Beijing 100088, China | | SU Xu | National Institute for Radiological Protection and Nuclear Safety, China CDC, Beijing 100088, China | | BAI Yushu | National Institute for Radiological Protection and Nuclear Safety, China CDC, Beijing 100088, China | | 王菊芳 | 中国科学院近代物理研究所 | | 马剑锋 | National Institute for Radiological Protection and Nuclear Safety, China CDC, Beijing 100088, China | | 黄绮龙 | National Institute for Radiological Protection and Nuclear Safety, China CDC, Beijing 100088, China | | 关树荣 | National Institute for Radiological Protection and Nuclear Safety, China CDC, Beijing 100088, China | | 李文建 | 中国科学院近代物理研究所 |
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| Abstract:: |
| Objective To establish the dose-effect curve of micronuclei for human peripheral blood lymphocytes after irradiation with heavy ion beams 12C6+ . Methods Heparinized whole blood samples were irradiated with heavy ion beams 12C6+, having 2 different dose-rate values (dose-rate=1 Gy/min and 3 Gy/min, mean LET=36 70 keV/μm), accelerated by a Heavy Ion Research Facility in Lanzhou at the Institute of Modern Physics, Chinese Academy of Sciences.Micronuclei in binuclear lymphocytes (CB method) were scored. Results At the absorbed dose range of 0-6 Gy, the CB micronucleus frequency increased with the increase of absorbed dose.The best-fitted equation is Y=665 09×D0 .85 . Conclusion At the absorbed dose range of 0-6 Gy, the relationship between absorbed dose and micronucleus frequency of human peripheral blood lymphocytes induced by heavy ion beams 12C6+ is exponential. |
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