| WANG Mingxi,ZHANG Liang'an,WANG Yong,et al.A study of microscopic dose rate distribution of 99Tcm-MIBI in the liver of mice[J].Chinese Journal of Radiological Medicine and Protection,2002,22(5):377-379 |
| A study of microscopic dose rate distribution of 99Tcm-MIBI in the liver of mice |
| Received:July 02, 2001 |
| DOI： |
| KeyWords:Microdosimetry Absorbed dose rate MIBI Autoradiography MIRD |
| FundProject: |
| Author Name | Affiliation | | WANG Mingxi | Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin 300192, China | | ZHANG Liang'an | Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin 300192, China | | WANG Yong | Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin 300192, China | | 戴光复 | Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin 300192, China |
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| Abstract:: |
| Objective A microdosimetry model was tried to develop an accurate way to evaluate absorbed dose rates in target cell nuclei from radiopharmaceuticals. Methods Microscopic frozen section autoradiography was used to determine the subcellular locations of 99 Tc m- MIBI relative to the tissue histology in the liver of mice after injection of 99 Tc m- MIBI via tail for two hours,and a mathematical model was developed to evaluate the microscopic dose rates in cell nuclei.The Medical Internal Radiation Dose(MIRD) schema was also used to evaluate the dose rates at the same time,and a comparison of the results of the two methods was conducted to determine which method is better to accurately estimate microscopic dose rates. Results The spatial distribution of 99 Tc m- MIBI in the liver of mice at subcellular level was not uniform,and the differences between the microdosimetry model and MIRD schema were significant( P <0. 01). Conclusion The microdosimetry model established in this test could be used as a substitute for MIRD schema to evaluate the dose of not uniformly distributed 99 Tc m labeled pharmaceuticals at the microscopic level; |
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