| JU Yongjian,ZHANG Liang'an,DAI Guangfu.Research on relationship between dose per fraction and therapeutic effect in fractionated radiotherapy with a tumor control probability model[J].Chinese Journal of Radiological Medicine and Protection,2002,22(5):368-371 |
| Research on relationship between dose per fraction and therapeutic effect in fractionated radiotherapy with a tumor control probability model |
| Received:January 09, 2002 |
| DOI： |
| KeyWords:Fractionated radiotherapy Dose Tumor Control Probability(TCP) |
| FundProject:国家自然科学基金资助项目(39670228) |
| Author Name | Affiliation | | JU Yongjian | Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tiangjin 300192, China | | ZHANG Liang'an | Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tiangjin 300192, China | | DAI Guangfu | Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tiangjin 300192, China | | 孙福印 | Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tiangjin 300192, China | | 苑淑渝 | Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tiangjin 300192, China |
|
| Hits: 2687 |
| Download times: 2020 |
| Abstract:: |
| Objective To study whether the effect can be improved by using unequal dose per fraction in fractionated radiotherapy with the given overall treatment dose and time. Methods Referring to the calculating formula of cell surviving probability,a new tumor control probability(TCP) calculating model following the fractionated radiotherapy has been set up.Then with four assumed fractionated dose protocols(fractionated dose increase or decrease in a week or in the whole treatment time),the TCP value will be calculated with the calculation model to get the relationship curves of some interested variables. Results The calculation results show that the four assumed unequal fractionated dose(UEFD) protocols were better than the conventional equal fractionated dose(EFD)protocol.The more uneven fractionated dose distribution was the better TCP results would be. Conclusion Given the overall treatment dose and time,treatment with UFED protocols can get better therapeutic effect than treatment with EFD protocol theoretically. |
| HTML View Full Text View/Add Comment Download reader |
| Close |
|
|
|
