| ZHOU Lixia,ZHAO Qingqiu,CAO Cuili.The changes of the rat glioma cell apoptosis and proliferation after gamma knife treatment[J].Chinese Journal of Radiological Medicine and Protection,2002,22(5):349-351 |
| The changes of the rat glioma cell apoptosis and proliferation after gamma knife treatment |
| Received:October 15, 2001 |
| DOI： |
| KeyWords:Glioma Apoptosis Proliferation Gamma knife |
| FundProject:河北省卫生厅立项资助课题(01025) |
|
| Hits: 2828 |
| Download times: 2056 |
| Abstract:: |
| Objective To evaluate the changes of apoptosis level and proliferated activity of the rat glioma model before and after gamma knife treatment. Methods 50 rats planted with C6 glioma cell were treated with gamma knife,at different time before and after irradiation,to observe the apoptosis of the glioma cell by flow cytometry and the proliferated activity by PCNA immunohistochemistry. Results The apoptosis rate was increased significiently after gamma knife treatment( P <0 .01),and reached peak at the 48th h; The positive cells number of PCNA the treatment group is significantly less than the control group,and continued to decrease with the following time point. Conclusion In addition to the necrosis,the decrease of the proliferation level and the increasing of the apoptosis rate may also the factors which inhibit the tumor growing after gamma knife irradition. |
| HTML View Full Text View/Add Comment Download reader |
| Close |
