| MENG Dongya,XUE Wencheng,FU Weixin.Inhibitory action of antisense oligodeoxynucleotide on radiotherapy-induced expression of vascular endothelial growth factor(VEGF) in a liver cancer cell line[J].Chinese Journal of Radiological Medicine and Protection,2002,22(5):337-339 |
| Inhibitory action of antisense oligodeoxynucleotide on radiotherapy-induced expression of vascular endothelial growth factor(VEGF) in a liver cancer cell line |
| Received:November 30, 2001 |
| DOI： |
| KeyWords:Radiotherapy Tumor Vascular endothelial growth factor Antisense oligodeoxynucleotide |
| FundProject:辽宁省自然科学基金资助项目(002032) |
| Author Name | Affiliation | | MENG Dongya | General Hospital of Shenyang Military Region, Shenyang 110015, China | | XUE Wencheng | General Hospital of Shenyang Military Region, Shenyang 110015, China | | FU Weixin | General Hospital of Shenyang Military Region, Shenyang 110015, China | | 胡华 | General Hospital of Shenyang Military Region, Shenyang 110015, China | | 罗军 | General Hospital of Shenyang Military Region, Shenyang 110015, China | | 李玉 | General Hospital of Shenyang Military Region, Shenyang 110015, China |
|
| Hits: 2276 |
| Download times: 1874 |
| Abstract:: |
| Objective To study the mechanism of serum VEGF increase in tumor patients during radiotherapy and the inhibitory action of its antisense oligodeoxynucleotide (AS -ODN) on expression of VEGF protein induced by radiotherapy in a liver cancer cell line. Methods To detect the change of the serum VEGF in tumor patients during radiotherapy dynamically and the inhibitory action of the (AS -ODN) on expression of VEGF induced by radiotheraphy in a liver cancer cell line. Results The changes of the serum VEGF in four patients receiving radiotherapy with watched continuously.Their levels of serum VEGF began to increase during radiotherapy with the peak value appeared in the first two weeks,and then declined to the pre radiotherapy range.Irradiating the liver cancer cells with X rays significantly increased the VEGF expression and secretion.The level of VEGF protein in the patient group treated with AS -ODN and X irradiation was significantly than that of the group treated with X irradiation only. Conclusion The induction of VEGF protein expression by X irradiation in tumor cells may result in increase of the serum VEGF in the tumor patients during radiotherapy and the induction can be blocked by VEGF AS- ODN. |
| HTML View Full Text View/Add Comment Download reader |
| Close |
