| LIANG Li,LI Xinfang.Effects of total base of Sophora alopecuroides on lipid peroxidation of 60Co γ-rays irradiated mice[J].Chinese Journal of Radiological Medicine and Protection,2002,22(5):319-321 |
| Effects of total base of Sophora alopecuroides on lipid peroxidation of 60Co γ-rays irradiated mice |
| Received:November 20, 2001 |
| DOI： |
| KeyWords:Sophora alopecuroides Radiation injury Antioxidation |
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| Abstract:: |
| Objective To study the effects of total base of Sophora alopecuroides on lipid peroxidation of irradiated mice. Methods The mice were treated orally with different doses of total base of Sophora alopecuroides,after exposed to whole body 60 Co γ-rays at a dose of 5.0 Gy.The content of MDA in the liver and activities of Se GSH PX,SOD,GPT,GOT were measured. Results After irradiation,the general status of the mice were changed such as hair deprivation,body weight reduction,blood spots appeared on the tail.Activities of Se GSH PX,SOD decreased remarkablely,whereas those of GPT and GOT increased.MDA contents increased obviously.Oral administration of total base of Sophora alopecuroides could accelerate restoration of these indexs. Conclusion Total base of Sophora alopecuroides has certain protective effects on irradiated mice,the mechanism of which may be related with antioxidation. |
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