| ZHU Yibei,WANG Yuedan,XI Hong,et al.The effects of γ-radiation on dendritic cells and its mechanisms[J].Chinese Journal of Radiological Medicine and Protection,2002,22(5):315-318 |
| The effects of γ-radiation on dendritic cells and its mechanisms |
| Received:December 15, 2001 |
| DOI： |
| KeyWords:ray Dendritic cells Biological function |
| FundProject:IAEA协作研究基金项目(CPR9025) |
| Author Name | Affiliation | | ZHU Yibei | Biotechnology Institute, Soochow University, Suzhou 215007, China | | WANG Yuedan | Biotechnology Institute, Soochow University, Suzhou 215007, China | | XI Hong | Biotechnology Institute, Soochow University, Suzhou 215007, China | | 顾宗江 | Biotechnology Institute, Soochow University, Suzhou 215007, China | | 古涛 | Biotechnology Institute, Soochow University, Suzhou 215007, China | | 谢炜 | Biotechnology Institute, Soochow University, Suzhou 215007, China | | 强亦忠 | Biotechnology Institute, Soochow University, Suzhou 215007, China | | 张学光 | Biotechnology Institute, Soochow University, Suzhou 215007, China |
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| Abstract:: |
| Objective To study the effects of γ-radiation on dendritic cells(DCs). Methods Monocyte derived DCs were irradiated with γ-ray.Flow cytometric analysis,cell counting,and mixed lymphocyte reaction were used to study the effects of γ-radiation on biological functions of DCs. Results γ-radiation could inhibit the proliferation of DCs in vitro, down regulate the expression of GM CSFR,Flt 3 and gp130,while up regulate CD80,CD86 and HLA DR.Moreover γ-radiation enhanced DCs' potention to activate the proliferation of T cells and reduced DCs' ability for Ag capture. Conclusion γ-radiation may effect the maturation and functions of DCs. |
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