| YANG Zhenguo,WANG Dewen,SONG Liangwen,et al.lnhaling nitric oxide to prevent and cure radiation interstitial pneumonia[J].Chinese Journal of Radiological Medicine and Protection,2002,22(4):288-290 |
| lnhaling nitric oxide to prevent and cure radiation interstitial pneumonia |
| Received:September 21, 2001 |
| DOI： |
| KeyWords:Nitric oxide Radiation interstitial pneumonia |
| FundProject:国家自然科学基金资助项目(29807213) |
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| Abstract:: |
| Objective To investigate the effect of inhaling nitric oxide to prevent and cure radiation interstitial pneumonia. Methods The whole rat thorax of all rats was irradiated with 30 Gy 60 Co γ rays and a pulmonary fibrosis model was made at month 3 after irradiation.The starting time of inhaling NO was one day before (B and C groups) or one month after (D and E groups) irradiating, respectively, and the duration of inhalation was one month for every group.The concentration of NO inhaled was 20 ppm (B and D groups) and 10 ppm (C and E groups). Group A was not treated with NO.The lung specimens were harvested 1 w, 1 m, 3 m and 6 m after irradiation. Results Mortalities of group B and group C were 10% and 5%, respectively, which were lower than that of group A (22.6%), group C(34.3%) and group D(14%).Acute interstitial pneumonia was observed in each group at 1 month after irradiation.But the inflammatory reaction and tissue damage in group B and C were slighter than other groups.The ratio of lung weight to body weight in group A was higher than that of groups B and C (P <0. 05).At month 6 after irradiation, patches of fibrosis were formed in group A, which was mainly found around bronchi blood vessels and the apex of lungPO 2 was decreased in group A significantly compared with other groups(P <0.05).In groups B and C slight focal hyperplasia and fibrosis were found in the apex of lung.In groups D and E, large areas of proliferation were seen, and mainly in the apex of lung. Conclusion By inhaling NO before irradiation, the radiation interstitial pneumonia can be attenuated, mortality decreased, and fibrosis delayed and reduced.For inhalation of NO after irradiation, the effect will be decreased. |
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