| ZHANG Wei,WANG Jixian,ZHAO Yongcheng.Association analysis of angiotensinogen gene 5'-flanking region C532T mutation and M235T polymorphism in essential hypertension of Chinese medical diagnostic X-ray workers[J].Chinese Journal of Radiological Medicine and Protection,2002,22(4):250-252 |
| Association analysis of angiotensinogen gene 5'-flanking region C532T mutation and M235T polymorphism in essential hypertension of Chinese medical diagnostic X-ray workers |
| Received:February 06, 2002 |
| DOI： |
| KeyWords:Medical diagnostic X-ray worker Essential hypertension Angiotensinogen gene Inonizing radiation |
| FundProject:日本体质研究会基金资助项目 |
| Author Name | Affiliation | | ZHANG Wei | Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China | | WANG Jixian | Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China | | ZHAO Yongcheng | Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China | | 樊体强 | Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China | | 牛津梁 | Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China | | 赵志刚 | Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China | | 田素青 | Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China | | 张亚利 | Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China |
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| Abstract:: |
| Objective To investigate whether angiotensinogen(AGT)gene 5'-flanking region C532T mutation and M235T polymorphism are associated with essential hypertension(EH) and the joint effect of the two sites. Methods A case-control study was carried out using 137 cases of essential hypertension and 114 cases of control.The C532T mutation and M235T polymorphism of the angiotensinogen gene were determined by polymerase chain reaction and restriction fragment length polymorphism (PCR/RFLP) analysis. Results The differences of genotype distribution of the AGT gene between cases having a family history of hypertension and controls without that history were statistically significant.(MT 0.18, TT 0.77 and MM 0.05 for case genotype vs MT 0.35, TT 0.57 and MM 0.08 for control, P =0. 031) A correlation between M235T and C532T molecular variant of AGT gene to hypertension was found. Conclusion Combinations of variations in angiotensinogen gene and occupational factors might associate with essential hypertension. |
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