| WNAG Zuoyuan.Relation between indoor radon and lung cancer[J].Chinese Journal of Radiological Medicine and Protection,2002,22(3):209-214 |
| Relation between indoor radon and lung cancer |
| Received:July 16, 2001 |
| DOI： |
| KeyWords:Exposure Errors Lung cancer Radiation Radon |
| FundProject:美国国立卫生研究院资助项目(NO1CP50509) |
| Author Name | Affiliation | | WNAG Zuoyuan | Laboratory of Industrial Hygiene, Ministry of Health, Beijing 100088 | | Lubin JH | National Institute of Cancer, USA | | 王陇德 | 卫生部 | | 张守志 | Laboratory of Industrial Hygiene, Ministry of Health, Beijing 100088 | | Boice JD Jr | 美国国际流行病研究所 | | 崔宏星 | Laboratory of Industrial Hygiene, Ministry of Health, Beijing 100088 | | 张淑蓉 | Laboratory of Industrial Hygiene, Ministry of Health, Beijing 100088 | | Conrath SC | 美国环境保护局 | | 夏英 | Laboratory of Industrial Hygiene, Ministry of Health, Beijing 100088 | | 尚兵 | Laboratory of Industrial Hygiene, Ministry of Health, Beijing 100088 | | BrennerA | National Institute of Cancer, USA | | 雷苏文 | Laboratory of Industrial Hygiene, Ministry of Health, Beijing 100088 | | Metayer KC | National Institute of Cancer, USA | | 曹吉生 | Laboratory of Industrial Hygiene, Ministry of Health, Beijing 100088 | | Chen KW | National Institute of Cancer, USA | | 雷淑杰 | Laboratory of Industrial Hygiene, Ministry of Health, Beijing 100088 | | Kleinerman RA | National Institute of Cancer, USA |
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| Abstract:: |
| Objective Low level of exposures to residential radon and dosimetric uncertainties due to mobility have hampered the evaluation of lung cancer risk and the comparison to radonexposed miners.To address these limitations,the authors conducted a casecontrol study in a predominantly rural area of China with low mobility and high radon levels.Methods Cases studied including all lung cancer patients diagnosed between Ja nuary 1994 and April 1998,aged 30-75 years,and resided in two prefectures of Gansu Province.Controls were randomly selected from census lists and matched on age sex and prefecture.Radon detectors were placed in all houses having been occupied two or more years in the past 530 years prior to enrollment.Measurements covered 77% of the possible exposure time.Results Mean radon concentrations were 230 4 Bq/m3 for the cases( n =768) and 222.2 Bq/m3 for the controls( n =1 659).Lung cancer risk increased along with increase of the radon level( P <0.001).Based on a linear model,the excess odds ratio(EOR)at 100 Bq/m3 was 0.19(95% CI:0.05,0 47)for all subjects,and 0.31(95%CI:0.10,0.81)for subjects with 100% coverage of the exposure interval.Adjusting for exposure uncertainties increased estimates about 70%.Conclusion The results support increased lung cancer risks with indoor radon exposures,which may equal to or exceed extrapolationbased risks from miner data. |
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