| SUN Suping,CAI Jianming,XIANG Yingsong,et al.Experinmental study on relationship between expression of SDF-1 and homing of hematopoietic cells[J].Chinese Journal of Radiological Medicine and Protection,2002,22(3):201-203 |
| Experinmental study on relationship between expression of SDF-1 and homing of hematopoietic cells |
| Received:June 29, 2001 |
| DOI： |
| KeyWords:Allogeneic mouse Bone marrow transplantation Homing SDF-1 |
| FundProject:国家自然科学基金资助项目(39770329,3960077) |
| Author Name | Affiliation | | SUN Suping | Department of Radiation Medicine, Second Military Medical University, Shanghai 200433, China | | CAI Jianming | Department of Radiation Medicine, Second Military Medical University, Shanghai 200433, China | | XIANG Yingsong | Department of Radiation Medicine, Second Military Medical University, Shanghai 200433, China | | 赵芳 | Department of Radiation Medicine, Second Military Medical University, Shanghai 200433, China | | 黄定德 | Department of Radiation Medicine, Second Military Medical University, Shanghai 200433, China | | 高建国 | Department of Radiation Medicine, Second Military Medical University, Shanghai 200433, China | | 杨如俊 | Department of Radiation Medicine, Second Military Medical University, Shanghai 200433, China |
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| Abstract:: |
| Objective To investigate the role of chemoattractant SDF-1 in of homing hematopoietic cells.Methods A mouse allogeneic bone marrow transplantation model and double staining of immunohistochemistry were used in this study.Relationship between expression of chemoattractant SDF-1 and of homing hematopoietic cells was observed.Results In bone marrow,SDF-1 was mainly expressed at sites near endosteum,in microvessel endothelium,osteocyte and around donor cells.Contrast to nonirradiation group,SDF-1 was significantly expressed by osteocytes,and at sites near endosteum in the irradiation group, suggesting that pretreatment with irradiation might enhance secretion of SDF-1 by bone marrow stromal cells and SDF-1 could have a close relation with homing cells.Conclusion Pretreatment with irradiation might be one of the stimulating factors significantly increasing the level of SDF-1 produced by bone marrow stromal cells and the chemoattractant SDF-1 could play an important role in homing of hematopoietic cells. |
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