| LIU Jianzhong,ZHOU Yuanguo,CHENG Tianmin.Regularity of wound healing in rats irradiated locally with different doses of soft X-rays[J].Chinese Journal of Radiological Medicine and Protection,2002,22(3):183-186 |
| Regularity of wound healing in rats irradiated locally with different doses of soft X-rays |
| Received:November 19, 2001 |
| DOI： |
| KeyWords:Soft X ray Local irradiation Wound healing |
| FundProject:国家重点基础研究发展规划“973”专项经费资助项目(G1999054205) |
| Author Name | Affiliation | | LIU Jianzhong | Molecular Biology Center, Research Institute of Surgery Daping Hospital, Third Military Medical University, Chongqing 400042, China | | ZHOU Yuanguo | Molecular Biology Center, Research Institute of Surgery Daping Hospital, Third Military Medical University, Chongqing 400042, China | | CHENG Tianmin | 第三军医大学预防医学系全军复合伤研究所 | | 周萍 | Molecular Biology Center, Research Institute of Surgery Daping Hospital, Third Military Medical University, Chongqing 400042, China | | 刘霞 | Molecular Biology Center, Research Institute of Surgery Daping Hospital, Third Military Medical University, Chongqing 400042, China | | 李平 | Molecular Biology Center, Research Institute of Surgery Daping Hospital, Third Military Medical University, Chongqing 400042, China |
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| Abstract:: |
| Objective To study the regular patter of wound healing in rats irradiated locally with different doses of soft X rays.Methods Rats were locally irradiated,and wounded immediately thereafter.Gross observation,histopathology and immunohistochemistry examinations,and image analysis were used to study the wound healing process.Results We found that the delayed time of wound healing induced by soft X ray irradiation of 0.50,1.01,1.96,3.26,4.00,5.21 Gy was 1.6,4.2,5.4,6.6,8.2 and 9.4 days,respectively.Irradiation with 7.0 and 10.0 Gy caused failare of wound healing (up to 40 days).Compared to the non irradiated wounds,the healing rates of irradiation impaired wounds were lower during the whole healing process.From day 3 to day 9 after irradiation,the healing rates decreased along with increase of the radiation dose,indicating the key phase of wound healing was delayed.After irradiation,the collagen synthesis was decreased,its arrangement was disordered,and the structure of granulation tissue was irregular.Conclusion Soft X rays irradiation may cause a delay of wound healing in a dose dependent manner,and irradiation with 7.0 and 10.0 Gy causes failure of wound healing. |
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