| ZHANG Xiaoqi,LIU Xusheng,LIU Shuang,et al.Effect of vascular endothelial growth factor on irradiated primary human umbilical vein endothelial cells[J].Chinese Journal of Radiological Medicine and Protection,2002,22(3):178-180 |
| Effect of vascular endothelial growth factor on irradiated primary human umbilical vein endothelial cells |
| Received:November 19, 2001 |
| DOI： |
| KeyWords:Human umbilical vein endothelial cells Irradiation injury Vascular endothelial growith factor |
| FundProject:国家重点基础研究发展规划“973”专项经费资助项目(G1999054205) |
| Author Name | Affiliation | | ZHANG Xiaoqi | Institute of Burn Research, Southwestern Hospital, Third Military Medical University, Chongqing 400038, China | | LIU Xusheng | Institute of Burn Research, Southwestern Hospital, Third Military Medical University, Chongqing 400038, China | | LIU Shuang | Institute of Burn Research, Southwestern Hospital, Third Military Medical University, Chongqing 400038, China | | 刘亮 | Institute of Burn Research, Southwestern Hospital, Third Military Medical University, Chongqing 400038, China | | 冉新泽 | 预防医学系全军复合伤研究所 | | 程天民 | 预防医学系全军复合伤研究所 |
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| Abstract:: |
| Objective To explore the effect of vascular endothelial growth factor on irradiated primary human umbilical vein endothelial cells(HUVECs).Methods HE staining and MTT method were employed to observe the effects of irradiation dose and VEGF on morphology and proliferation of EC.Results The results indicated that there were obvious changes in morphology of irradiated endothelial cells and a small dose (6 Gy) of radiation could enhance but a large dose (12 Gy) inhibit the activity of endothelial proliferation.VEGF was found to be evidently antagonistic against endothelial injury by irradiation of 12 Gy.Conclusion VEGF could be an antagonist to radiation injury with promising future in wound repair. |
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