| AI Guoping,SU Yongping,YAN Guohe.Effects of bone marrow mesenchymal stem cells on healing of wound combined with local radiation injury[J].Chinese Journal of Radiological Medicine and Protection,2002,22(3):164-167 |
| Effects of bone marrow mesenchymal stem cells on healing of wound combined with local radiation injury |
| Received:November 19, 2001 |
| DOI： |
| KeyWords:Mesenchymal stem cells Wound combined radiation injury Healing of wounded tissue |
| FundProject:国家重点基础研究发展规划“973”专项经费资助项目(G1999054205) |
| Author Name | Affiliation | | AI Guoping | Institute of Combined Injury of PLA, School of Preventive Medicine, Third Military Medical University, Chongqing 400038, China | | SU Yongping | Institute of Combined Injury of PLA, School of Preventive Medicine, Third Military Medical University, Chongqing 400038, China | | YAN Guohe | Institute of Combined Injury of PLA, School of Preventive Medicine, Third Military Medical University, Chongqing 400038, China | | 冉新泽 | Institute of Combined Injury of PLA, School of Preventive Medicine, Third Military Medical University, Chongqing 400038, China | | 刘晓宏 | Institute of Combined Injury of PLA, School of Preventive Medicine, Third Military Medical University, Chongqing 400038, China | | 罗成基 | Institute of Combined Injury of PLA, School of Preventive Medicine, Third Military Medical University, Chongqing 400038, China | | 程天民 | Institute of Combined Injury of PLA, School of Preventive Medicine, Third Military Medical University, Chongqing 400038, China |
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| Abstract:: |
| Objective To explore the effects of bone marrow mesenchymal stem cells(MSC) on healing of wounds combined with local skin irradiation injury.Methods MSC were injected into the wound combined with local skin irradiation injury.Light and electron microscopy,fibroblast and capillary vessel counts,detection of hydroxyproline content in the wound and demonstration of MSC distribution by fluorescence examination were carried out.Results MSC could accelerate the speed of wound healing,The number of fibroblasts and capillary vessels increased obviously during 5 to 20 days after wounding.Granular tissues were abundant in the wound,and the content of hydroxyproline increased in the MSC treated groups.The fluorescence labeling showed that MSC could be found during 1 to 20 days after injection.Conclusion MSC can remain alive in the wound for a long time and surely promote wound healing. |
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