| SHI Chunmeng,CHENG Tianmin,QU Jifu.Nerve growth factor promotes wound healing and hematopoietic recovery in irradiated mice[J].Chinese Journal of Radiological Medicine and Protection,2002,22(3):160-162 |
| Nerve growth factor promotes wound healing and hematopoietic recovery in irradiated mice |
| Received:November 19, 2001 |
| DOI： |
| KeyWords:Combined radiation injury Nerve growth factor Wound healing Hematopoietic recovery |
| FundProject:国家重点基础研究发展规划“973”专项经费资助项目(G1999054205);重庆市应用基础研究资助项目(20016822) |
| Author Name | Affiliation | | SHI Chunmeng | Institute of Combined Injury of PLA, School of Preventive Medicine, Third Military Medical University, Chongqing 400038, China | | CHENG Tianmin | Institute of Combined Injury of PLA, School of Preventive Medicine, Third Military Medical University, Chongqing 400038, China | | QU Jifu | Institute of Combined Injury of PLA, School of Preventive Medicine, Third Military Medical University, Chongqing 400038, China | | 冉新泽 | Institute of Combined Injury of PLA, School of Preventive Medicine, Third Military Medical University, Chongqing 400038, China |
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| Abstract:: |
| Objective To investigate the effects of nerve growth factor(NGF) isolated from human plancenta on the process of skin wound healing and hematopoietic recovery of mice after totalbody γ-irradiation.Methods Mice were irradiated with 5 Gy of γ-rays.Thirty minutes after irradiation,a circular skin excision with 2 cm in diameter was made on the back of the animal.NGF (50U/day) was administered intraperitoneally and also by topical application for five consecutive days.Survival rate of mice,peripheral white blood cell count,bone marrow nucleated cell count,residual area of wound,number of fibroblasts and capillary vessels in wound tissue were selected as parameters for study.Results NGF could increase survival rate,the number of peripheral white blood cells and bone marrow nucleated cells and could also promote skin healing and increase the numbers of fibroblasts and capillary vessels in the wound.Conclusion NGF could promote wound healing,hematopoietic recovery and survival rate of irradiated animals.This may have significance in basic research and clinical treatment of combined radiation injuries. |
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