| RAN Xinze,CHENG Tianmin,LIN Yuan.Dose-effect relationships of total-body irradiation on healing of cutaneous wound[J].Chinese Journal of Radiological Medicine and Protection,2002,22(3):149-152 |
| Dose-effect relationships of total-body irradiation on healing of cutaneous wound |
| Received:November 19, 2001 |
| DOI： |
| KeyWords:Radiation injury Combined radiation-trauma injury Wound healing Dose-effect |
| FundProject:国家重点基础研究发展规划“973”专项经费资助项目(G1999054205) |
| Author Name | Affiliation | | RAN Xinze | Institute of Combined Injury of PLA, School of Preventive Medicine, Third Military Medical University, Chongqing 400038, China | | CHENG Tianmin | Institute of Combined Injury of PLA, School of Preventive Medicine, Third Military Medical University, Chongqing 400038, China | | LIN Yuan | Institute of Combined Injury of PLA, School of Preventive Medicine, Third Military Medical University, Chongqing 400038, China | | 屈纪富 | Institute of Combined Injury of PLA, School of Preventive Medicine, Third Military Medical University, Chongqing 400038, China | | 徐辉 | Institute of Combined Injury of PLA, School of Preventive Medicine, Third Military Medical University, Chongqing 400038, China | | 王军平 | Institute of Combined Injury of PLA, School of Preventive Medicine, Third Military Medical University, Chongqing 400038, China | | 粟永萍 | Institute of Combined Injury of PLA, School of Preventive Medicine, Third Military Medical University, Chongqing 400038, China | | 阎国和 | Institute of Combined Injury of PLA, School of Preventive Medicine, Third Military Medical University, Chongqing 400038, China | | 王文昌 | 卫生统计学教研室 |
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| Abstract:: |
| Objective To study the effects of dosage of totalbody irradiation on healing process of cutaneous wound.Methods Rats were irradiated with a 60Co γray source.The single dosage varied from 1 to 8 Gy.Within 1 h after irradiation,two full thickness circular wounds (22 mm) were produced on the back of animals,corresponding to 2.5% of total body surface area.Results After totalbody irradiation with 1,2,3,4,5,6,7,8 Gy combined with cutaneous wound,the rate of healing was obviously retarded along with the increase of irradiation dose.The surface of the wound remained was larger in the high dosage group as compared to that of the lower dosage ones.Taking 7 d after injury for example,there was 35.5% wound surface left unhealed in rats of the group with cutaneous wound only,while in the combined injury groups irradiated with 1 to 8 Gy,there were 35.4%,38.1%,41.6%,48.8%,53.9%,63.7%,69.2%,73.9% remained unhealed,respectively.Statistical analysis showed that there were marked correlation between irradiation dosage and the percentage of unhealed wound surface (Ý).Nine doseeffect relation formulas were derived according to the statistical results.Conclusion For soft tissue trauma combined with radiation injury,the delay of wound healing is definitely related to the dose of radiation inflicted. |
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