| LIN Hong,WU Wei,ZHANG Kunhe.The prophylactic and protective effects of egg yolk immunoglobulin against Escherichia coli on radiation-induced enteritis in rats[J].Chinese Journal of Radiological Medicine and Protection,2002,22(2):94-96 |
| The prophylactic and protective effects of egg yolk immunoglobulin against Escherichia coli on radiation-induced enteritis in rats |
| Received:August 10, 2001 |
| DOI： |
| KeyWords:Whole abdominal radiation Egg yolk immunoglobulin Bacteria translocation Endotoxin |
| FundProject:江西省科委Ⅱ级基金资助项目(F970506) |
| Author Name | Affiliation | | LIN Hong | The First Affiliated Hospital, Jiangxi Medical College, Nanchang 330006, China | | WU Wei | The First Affiliated Hospital, Jiangxi Medical College, Nanchang 330006, China | | ZHANG Kunhe | The First Affiliated Hospital, Jiangxi Medical College, Nanchang 330006, China | | 陈江 | The First Affiliated Hospital, Jiangxi Medical College, Nanchang 330006, China | | 黄德强 | The First Affiliated Hospital, Jiangxi Medical College, Nanchang 330006, China | | 汪泱 | The First Affiliated Hospital, Jiangxi Medical College, Nanchang 330006, China | | 曹勇 | The First Affiliated Hospital, Jiangxi Medical College, Nanchang 330006, China |
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| Abstract:: |
| Objective To observe the prophylactic and protective effects of egg yolk immunoglobulin (IgY)against Escherichia coli on radiation-induced enteritis in rats.Methods Thirty rats were randomly divided into three groups:normal control group (group A),radiation control group (group B) and IgY treatment group (group C).The rats of groups B and C were subjected to whole abdominal irradiation of 1000 cGy.Feeding IgY began since the day before irradiation in group C.Four days later,all the rats were killed and the intestinal bacteria translocation,the concentration of endotoxin in blood,and pathological changes of intestinal mucosa were measured or observed.Results Bacteria translocation was not found in group A,but evident in group B(96.7%),and much lighter in group C(13.3%) than in group B.The concentration of endotoxin in blood was very low in group A (0.001 EU/ml) and very high in group B (0.829 EU/ml),but it was much lower in group C(0.249 EU/ml) than in group B.The villus edema,infiltration of inflammatory cells in mucosa and epithelial desquamation were found in group B,but these pathological changes were much milder in group C and not found at all in group A.ConclusionWhole abdomen irradiation will evidently cause enteritis in rats,and followed by bacteria translocation and endotoxinemia;IgY against Escherichia coli can diminish these changes. |
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