| SHU Chongxiang,CHENG Tianmin,YAN Guohe.Effects of whole body γ irradiation on skin wound cells and the repaired-promoting action of W11-a12[J].Chinese Journal of Radiological Medicine and Protection,2002,22(2):90-93 |
| Effects of whole body γ irradiation on skin wound cells and the repaired-promoting action of W11-a12 |
| Received:September 20, 2001 |
| DOI： |
| KeyWords:Wound healing Radiation injury W11-a12 bFGF |
| FundProject:国家973重点基础研究发展规划资助项目(G1999054205);重庆市院士基金资助项目(985081) |
| Author Name | Affiliation | | SHU Chongxiang | Institute of Combined Injury, Faculty of Prevention Medicine, Third Military Medical University Chongqing 400038, China | | CHENG Tianmin | Institute of Combined Injury, Faculty of Prevention Medicine, Third Military Medical University Chongqing 400038, China | | YAN Guohe | Institute of Combined Injury, Faculty of Prevention Medicine, Third Military Medical University Chongqing 400038, China | | 冉新泽 | Institute of Combined Injury, Faculty of Prevention Medicine, Third Military Medical University Chongqing 400038, China |
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| Abstract:: |
| Objective To study the effects of 6 Gy whole body γ irradiation on components of wound cells and the repair-promoting action of W11-a12, an extract from Periplaneta americana.Methods After mice were received 6 Gy gamma ray irradiation,the area of healing range in wound cross section,the cellular infiltration of wound and the content of basic fibroblast growth factor (bFGF) in wound epithelial cells were observed and the healing-promoting effect of W11-a12 on the radiation-impaired wound was investigated.Results The area of healing range in cross section was decreased,various infiltrated cells were all inhibited by radiation,but the range of inhibition was more or less different,and the descending order of severity was as follows:macrophages,vascular endothelial cells,fibroblasts and epithelial cells.The content of bFGF in epithelial cells was decreased.W11-a12 had benefical heal-promoting effect on radiation-impaired wound:it increased cellular infitration and promoted synthesis and secretion of bFGF in epithelial cells.ConclusionThe depletion of wound cells is mainly responsible for the healing deficits of radiation-impaired skin wound and W11-a12 enhances cell migration and proliferation and promotes synthesis and secretion of bFGF in epithelial cells. |
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