| XU Zhixiang,ZHANG Xueguang,ZHU Jiankun,et al.Flt3 ligand accelerates the recovery of the immune system in irradiated mice[J].Chinese Journal of Radiological Medicine and Protection,2002,22(2):86-89 |
| Flt3 ligand accelerates the recovery of the immune system in irradiated mice |
| Received:November 21, 2000 |
| DOI： |
| KeyWords:Cytokines Flt3 ligand Immune system |
| FundProject:国防科工委国防预研基金资助项目(Y5573162);国际原子能机构(IAEA)基金资助项目(CRP9025) |
| Author Name | Affiliation | | XU Zhixiang | Department of Immunology, Medical Biotechnology Institute, School of Life Science, Soochow University, Suzhou 215007, China | | ZHANG Xueguang | Department of Immunology, Medical Biotechnology Institute, School of Life Science, Soochow University, Suzhou 215007, China | | ZHU Jiankun | Department of Immunology, Medical Biotechnology Institute, School of Life Science, Soochow University, Suzhou 215007, China | | 徐颖 | Department of Immunology, Medical Biotechnology Institute, School of Life Science, Soochow University, Suzhou 215007, China | | 李颖 | Department of Immunology, Medical Biotechnology Institute, School of Life Science, Soochow University, Suzhou 215007, China | | 丁天 | 上海复旦大 | | 赵仁亮 | Department of Immunology, Medical Biotechnology Institute, School of Life Science, Soochow University, Suzhou 215007, China | | 於葛华 | Department of Immunology, Medical Biotechnology Institute, School of Life Science, Soochow University, Suzhou 215007, China | | 强亦忠 | Department of Immunology, Medical Biotechnology Institute, School of Life Science, Soochow University, Suzhou 215007, China |
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| Abstract:: |
| Objective To study the immunoprotective potential of Flt3 ligand (FL) alone or in combination with other cytokines in irradiated mice.Methods The number of peripheral blood cells was counted by using F-800 apparatus and the phenotype of lymphocytes was analyzed by flow cytometry.The pathological manifestations of spleen,thymus and lymph nodes were also evaluated.Results FL used alone before irradiation or in combination with other cytokines after irradiation could stimulate the recovery of peripheral white blood cells,especially CD8+ T lymphocytes,and accelerate the recovery of ratio of CD4+/CD8+ T lymphocytes.FL reduced immune tissue damage and stimulated recovery of spleen,thymus and lymph nodes.The administration of FL to mice prior to irradiation and,to a lesser extent,after irradiation,significantly enhanced survival rate of animals.ConclusionFL can stimulate not only the recovery of hematopoiesis,but also the improvement of immune function in irradiated mice.FL alone or in combination with other cytokines exerts a distinct radio-protection effect. |
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