| ZHU Jundong,SU Yongping,CHENG Tianmin.Effect of glucagon-like peptide 2 on recovery of intestinal function from radiation injury in mice[J].Chinese Journal of Radiological Medicine and Protection,2002,22(1):30-32 |
| Effect of glucagon-like peptide 2 on recovery of intestinal function from radiation injury in mice |
| Received:May 08, 2001 |
| DOI： |
| KeyWords:Glucagon-like peptide 2 Radiation injury Intestinal function Mice |
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| Abstract:: |
| Objective To investigate the effect of glucagon-like peptide 2(GLP-2) on recovery of intestinal epithelial function from radiation injury in mice. Methods Kunming mice received a single dose of 8 Gy total-body irradiation from 60 Co gamma-rays followed by treatment with GLP-2 or vehicle.Intestinal permeability,plasma endotoxin content,glucose absorption,and sucrase and lactase activities were measured on days 1,3,5 after treatment. Results In irradiated mice intestinal permeability and glucose absorption were significantly higher, and sucrase and lactase activities lower than those in normal mice on days 1,3,5(P<0^01 or P<005).Plasma endotoxin content in irradiated mice on days 1,3 was significantly higher than that in the normal mice (P<0.01 or P<0.05).In GLP-2-treated mice,intestinal permeability,glucose absorption,and plasma endotoxin content restored to normal on day 3 sucrase and lactase activities restored to normal on day 5. Conclusion GLP-2 can promote recovery of intestinal mucosal barrier function,digestion and absorption function from radiation injury. |
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