| JIA Guanghong,MA Yexin,XIAO Jianming.Inhibition of MAPK and PKC pathways by 60Co γ-radiation in cultured vascular smooth muscle cells[J].Chinese Journal of Radiological Medicine and Protection,2002,22(1):25-26 |
| Inhibition of MAPK and PKC pathways by 60Co γ-radiation in cultured vascular smooth muscle cells |
| Received:July 18, 2000 |
| DOI： |
| KeyWords:Radiation Smooth muscle cell Signal transduction Protein kinases |
| FundProject:湖北省科委“九五”攻关基金资助项目(962P1101) |
| Author Name | Affiliation | | JIA Guanghong | Department of Cardiology, Tongji Hospital, Tongji Medical University, Wuhan 430030, China | | MA Yexin | Department of Cardiology, Tongji Hospital, Tongji Medical University, Wuhan 430030, China | | XIAO Jianming | Department of Cardiology, Tongji Hospital, Tongji Medical University, Wuhan 430030, China |
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| Abstract:: |
| Objective To investigate the signal transduction pathways inhibited by 60 Co γ-radiation in cultured vascular smooth muscle cells (VSMC). Methods The cultured VSMC were irradiated with 60 Co γ-radiation of 3.5,7.0,and 14 Gy respectively.VSMC proliferation was measured by 34+3H-TdR incorporation,while PKC,MAPK activities were determined by radioactivity assay. Results Proliferation of VSMC was inhibited by 7.0,14 Gy 60 Co γ-irradiation and the activities of PKC,MAPK were decreased significantly. Conclusion Inhibitory effect of 7.0,14 Gy 60 Co γ-irradiation on proliferation of VSMC might be resulted from decrease of the activity of PKC,MAPK. |
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