| CHEN Jianfang,ZHOU Ping,ZHENG Songyang.Effect of zinc and vitamin E on lipid peroxidation and membrane fluidity in liver with radiation injury[J].Chinese Journal of Radiological Medicine and Protection,2002,22(1):22-24 |
| Effect of zinc and vitamin E on lipid peroxidation and membrane fluidity in liver with radiation injury |
| Received:May 06, 2001 |
| DOI： |
| KeyWords:Zinc Vitamin E Liver Radiation injury Membrane fluidity Mice |
| FundProject:湖南省卫生厅基金资助项目(9804) |
| Author Name | Affiliation | | CHEN Jianfang | Isotope Laboratory, Xiangya School of Medicine, Central South University, Changsha 410078, China | | ZHOU Ping | Isotope Laboratory, Xiangya School of Medicine, Central South University, Changsha 410078, China | | ZHENG Songyang | Isotope Laboratory, Xiangya School of Medicine, Central South University, Changsha 410078, China | | 陈国华 | Isotope Laboratory, Xiangya School of Medicine, Central South University, Changsha 410078, China | | 王克超 | Isotope Laboratory, Xiangya School of Medicine, Central South University, Changsha 410078, China |
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| Abstract:: |
| Objective To evaluate the effect of zinc and vitamin E on protecting liver from radiation damage. Methods After a single 7.5 Gy whole-body irradiation by 60 Co gamma rays mice were fed with zinc and vitamin E,then LPO concentration and GSH-Px activity in liver homogenate were tested and changes of membrane fluidities in mitochondria and microsome were observed. Results After irradiation,the LPO concentration in liver homogenate increased significantly,whereas the activity of GSH-Px decreased.There were changes of membrane fluidities in both mitochondria and microsomes. Conclusions Zinc and vitamin E can inhibit lipid peroxidation and increase the activity of GSH-Px and membrane fluidity.They might have great potenials in protection against hepatic radiation injury. |
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