| .Effects of early escharectomy on rats with combined radiation-burn injury[J].Chinese Journal of Radiological Medicine and Protection,2002,22(1):19 |
| Effects of early escharectomy on rats with combined radiation-burn injury |
| Received:April 20, 2001 |
| DOI： |
| KeyWords:Combined radiation-burn injury Early escharectomy Wound healing |
| FundProject:全军医药卫生“九五”攻关课题基金资助项目(96L045) |
| Author Name | Affiliation | | 柳宪华 | 221005 江苏, 徐州市第三人民医院神经外科, 放疗中心 | | 胡殿雷 | 221005 江苏, 徐州市第三人民医院神经外科, 放疗中心 | | 于效良 | 221005 江苏, 徐州市第三人民医院神经外科, 放疗中心 | | 庄会林 | 221005 江苏, 徐州市第三人民医院神经外科, 放疗中心 | | 孙光远 | 221005 江苏, 徐州市第三人民医院神经外科, 放疗中心 | | 施鹏 | 221005 江苏, 徐州市第三人民医院神经外科, 放疗中心 | | 林野 | 221005 江苏, 徐州市第三人民医院神经外科, 放疗中心 | | 华庆云 | 221005 江苏, 徐州市第三人民医院神经外科, 放疗中心 |
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| Abstract:: |
| Objective To provide evidence for beneficial effect of clinical therapy with early escharectomy on survival and wound healing in rats with combined radiation-burn injury. Methods Rats were exposed to 5 Gy whole-body γ-ray irradiation from a 60 Co source and to thermal-radiation burn(10% TBSA, full thickness burn)successively by a 5 kW bromotungsten lamp.Then the animals were given anti-shock and anti-infection remedies.Early escharectomy and stitch(EES) at 24 h after injury, eschar-protecting treatment, or other treatment modarlities were carried out.The 60-day survival rate, the duration of wound healing and the changes of the body weight of animals were observed. Results The 60-day survival rate of EES group reached 78%, being higher than that of the no-escharectomy group(40%, P<0.05)and even higher than that of the escharectomy with non-stitch group(15%, P<0.01)and that of the control group(10%, P<0.01).Besides, in the EES group, the wound showed no sign of infection and healed well, and the body weights recovered faster. Conclusions EES is effective and available on this model of combined injuries.It is appropriate for operation at 24-48 h after injury. |
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