| RAN Xinze,LIU Xianhua,WANG Donghai.Effects of early escharectomy on rats with combined radiation-burn injury[J].Chinese Journal of Radiological Medicine and Protection,2002,22(1):17-19 |
| Effects of early escharectomy on rats with combined radiation-burn injury |
| Received:March 20, 2001 |
| DOI： |
| KeyWords:Combined radiation-burn injury Early escharectomy Wound healing |
| FundProject:全军医药卫生“九五”攻关课题基金资助项目(96L045) |
| Author Name | Affiliation | | RAN Xinze | Institute of Combined Injury of PLA, School of Preventive Medicine, Third Military Medical University, Chongqing 400038, China | | LIU Xianhua | Institute of Combined Injury of PLA, School of Preventive Medicine, Third Military Medical University, Chongqing 400038, China | | WANG Donghai | 太原市解放军二六四医院烧伤科 | | 何庆嘉 | Institute of Combined Injury of PLA, School of Preventive Medicine, Third Military Medical University, Chongqing 400038, China | | 程天民 | Institute of Combined Injury of PLA, School of Preventive Medicine, Third Military Medical University, Chongqing 400038, China | | 林远 | Institute of Combined Injury of PLA, School of Preventive Medicine, Third Military Medical University, Chongqing 400038, China |
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| Abstract:: |
| Objective To provide evidence for beneficial effect of clinical therapy with early escharectomy on survival and wound healing in rats with combined radiation-burn injury. Methods Rats were exposed to 5 Gy whole-body γ-ray irradiation from a 60 Co source and to thermal-radiation burn(10% TBSA,full thickness burn)successively by a 5 kW bromotungsten lamp.Then the animals were given anti-shock and anti-infection remedies.Early escharectomy and stitch(EES) at 24 h after injury,eschar-protecting treatment,or other treatment modarlities were carried out.The 60-day survival rate,the duration of wound healing and the changes of the body weight of animals were observed. Results The 60-day survival rate of EES group reached 78%,being higher than that of the no-escharectomy group(40%,P<0.05)and even higher than that of the escharectomy with non-stitch group(15%,P<0.01)and that of the control group(10%,P<0.01).Besides,in the EES group,the wound showed no sign of infection and healed well,and the body weights recovered faster. Conclusions EES is effective and available on this model of combined injuries.It is appropriate for operation at 24-48 h after injury. |
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