| SHU Chongxiang,YE Benlan,CHENG Tianmin.Effects of 5 Gy total-body irradiation and W11-a12 on ion channels of wound macrophages[J].Chinese Journal of Radiological Medicine and Protection,2001,21(6):417-420 |
| Effects of 5 Gy total-body irradiation and W11-a12 on ion channels of wound macrophages |
| Received:October 24, 2000 |
| DOI： |
| KeyWords:Irradiation Wound healing Macrophage Anion selective channel W11-a12 |
| FundProject:国家973基础重点研究发展规划资助项目(G1999054205);重庆市科委院士基金资助项目(98-5081) |
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| Abstract:: |
| Objective To study the effects of irradiation and W11-a12,a kind of repair promoting drug,on ion channels in membrane of macrophages from wound. Methods The activity of ion channel was recorded from cell-attached patches with patch clamp techniques. Results The effects of irradiation on ion channel in membranes of wound macrophages include:①decreasing the mean number of cells with ion channel openning spontaneously;②depressing the opening of Cl- and potassium channels by decreasing open-state probability,shortening open-time and prolonging close time.The effects of irradiation could be partly depressed by W11-a12. Conclusion Irradiation will depress the ion channel of macrophages from wound,which may be an important way in its depressing the function of macrophage. |
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