LIU Jiamei,CHEN Dong,ZHENG Yongchen,et al.Effect of low dose ionizing radiation on Bcl-2 transcription level of Peyer's patches in mouse[J].Chinese Journal of Radiological Medicine and Protection,2001,21(6):410-412
Effect of low dose ionizing radiation on Bcl-2 transcription level of Peyer's patches in mouse
Received:October 28, 2001  
DOI：
KeyWords:X-rays  Peyer's patches  Bcl-2
FundProject:国家教委回国人员科研启动资金;国家自然科学基金资助项目(39570188)
Author NameAffiliation
LIU Jiamei Department of Histology &
Embryology, Norman Bethune School of Medicine, Jilin University, Changchun 130021, China 
CHEN Dong Department of Histology &
Embryology, Norman Bethune School of Medicine, Jilin University, Changchun 130021, China 
ZHENG Yongchen 吉林大学第一临床学院中心实验室 
刘树铮 吉林大学卫生部放射生物学重点实验室 
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Abstract::
      Objective To study the effect of whole body irradiation (WBI) with different doses of X-rays on apoptosis in cells of mouse Peyers patches and its molecular mechanism. Methods RT-PCRwas used to detect the changes of Bcl-2 transcription level.Agarose electrophoresis and flow cytometry were used to detect the changes of DNAand apoptotic bodies in Peyers patches after WBIwith different doses of X-rays. Results The apoptotic was increased and Bcl-2 transcription level was decreased in Peyers patches after 2 Gy X-rays.The apoptotic rate was decreased and Bcl-2 transcription level was increased in Peyers patches after 75 mGy X-rays. Conclusion Bcl-2 participates in the regulation of radiation-induced apoptosis in Peyer's patches.
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