| XIA Ying,YANG Meiying,Lü Huimin,et al.p53 and k-ras mutations in lung cancer associated with residential radon exposure[J].Chinese Journal of Radiological Medicine and Protection,2001,21(6):404-405 |
| p53 and k-ras mutations in lung cancer associated with residential radon exposure |
| Received:April 17, 2001 |
| DOI： |
| KeyWords:Radon Lung cancer p53 PCR-SSCP Sequence analysis |
| FundProject:国家自然科学基金资助项目(39970235) |
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| Abstract:: |
| Objective The aim of this study was to analyze mutation of p53 and k-ras genes in lung cancer related to residential radon exposure. Methods PCR amplification,PCR-SSCP electrophoresis,and sequence analysis were carried out. Results Five of 9 lung cancer cases were found to be positive with p53 PCR-SSCP electrophoresis techniques,and in 3 among the 5 base substitution was observed. Conclusion Five of the seven cases of lung cancer 200-350 Bq·m-3 ·a-1 radon level had p53 gene mutation,which might be related to age and smoking status of the patients. |
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