| ZHAO Po,LI Zhijun,Lü Yali.Expression of telomerase reverse transcriptase in radiation-induced chronic human skin ulcer[J].Chinese Journal of Radiological Medicine and Protection,2001,21(6):401-403 |
| Expression of telomerase reverse transcriptase in radiation-induced chronic human skin ulcer |
| Received:November 23, 2000 |
| DOI： |
| KeyWords:Skin ulcer Radiation Telomerase |
| FundProject:国家自然科学基金资助项目(39470229) |
| Author Name | Affiliation | | ZHAO Po | Department of Pathology, Chinese General Hospital of People's Liberation Army, Beijing 100853, China | | LI Zhijun | Department of Pathology, Chinese General Hospital of People's Liberation Army, Beijing 100853, China | | Lü Yali | Department of Pathology, Chinese General Hospital of People's Liberation Army, Beijing 100853, China | | 钟梅 | Department of Pathology, Chinese General Hospital of People's Liberation Army, Beijing 100853, China | | 谷庆阳 | 北京放射医学研究所病理学研究室 | | 王德文 | 北京放射医学研究所病理学研究室 |
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| Abstract:: |
| Objective To inverstigate the expression of the catalytic subunit of telomerase,telomerase reverse transcriptase(TRT)and the possible relationship between the TRT and cancer transformation or poor healing in radiation-induced chronic ulcer of human skin. Methods Rabbit antibody against human TRT and SP immunohistochemical method were used to detect TRTexpression in 24 cases of formalin fixed,paraffin embeded human skin chronic ulcer tissues induced by radiation,5 cases of normal skin,2 of burned skin,and 8 of carcinoma. Results The positive rate for TRT was 58.3%(14/24)in chronic radiation ulcers,of which the strongly positive rate was 41.7%(10/24) and the weakly positive 16.7%(4/24),0% in normal(0/5)and burned skin(0/2),and 100% in carcinoma(8/8).The strongly positive expression of TRT was observed almost always in the cytoplasm and nucleus of squamous epithelial cells of proliferative epidermis but the negative and partly weakly positive expression in the smooth muscles,endothelia of small blood vessels and capillaries,and fibroblasts.Chronic inflammtory cells,plasmacytes and lymphocytes also showed weakly positive for TRT. Conclusion TRTexpression could be involved in the malignant transformation of chronic radiation ulcer into squamous carcinoma,and in the poor healing caused by sclerosis of small blood vessels and lack of granulation tissue consisting of capillaries and fibroblasts. |
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