| YU Hongsheng,LU Yanda.Effects of low dose radiation on tumor growth and changes of erythrocyte immune function and activity of SOD in tumor-bearing mice[J].Chinese Journal of Radiological Medicine and Protection,2001,21(5):354-356 |
| Effects of low dose radiation on tumor growth and changes of erythrocyte immune function and activity of SOD in tumor-bearing mice |
| Received:December 15, 2000 |
| DOI： |
| KeyWords:Low dose radiation S180 sarcoma TIL Erythrocyte immume function SOD |
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| Abstract:: |
| Objective To study the effect of low dose radiation on tumor growth and changes of erythrocyte immune function and activity of SODin the tumor bearing mice. Methods Kunming strain male mice were implanted with S180 sarcoma cells in the right inguen subcutaneously as an experimental in situ animal model.Six hours before implantaion the mice were given 75 mGy whole body Xray irradiation and tumor formation rate was counted 5 days late.From then,every two days the tumor volume was measured to draw a tumor growth curve.Fifteen days later,all mice were killed to measure the tumor weight,observe the necrosis area and the tumor infiltration lymphoreticular cells(TIL) in the tumor pathologically.At the same time,erythrocyte immune function and activity of SODwere tested. Results (1)The mice pre exposed to low dose radiation had a lower tumor formation rate than those without a pre exposed( P<0.05 ).(2)The tumor growth slowed down significantly in mice receiving a low does irradiation;The average tumor weight in mice receiving a low dose irradiation was lighter too( P< 0.05).(3)The tumor necrosis areas were larger and TILs were more in the irradiation group than those of the control growp.(4)The erythrocyte immune function and activity of SODin the irradiation group were all higher significantly than those of the control group( P <005). Conclusion Low dose radiation could markedly increase anti tumor ability of the organism and improve the erythrocyte immune function and activity of SODin red cells,suggesting it could be useful in clinical cancer treatment. |
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