| FAN Feiyue,YANG Suxia,CAO Zhenshan,et al.Relationship between cell transformation and DNA strand breaks induced by α-radiation[J].Chinese Journal of Radiological Medicine and Protection,2001,21(5):351-353 |
| Relationship between cell transformation and DNA strand breaks induced by α-radiation |
| Received:December 15, 2000 |
| DOI： |
| KeyWords:αparticle irradiation Cell transformation DNA strand breaks |
| FundProject: |
| Author Name | Affiliation | | FAN Feiyue | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | YANG Suxia | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | CAO Zhenshan | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | 李煜 | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | 朱茂祥 | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | 刘国廉 | Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China |
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| Abstract:: |
| Objective To inverstigate the quantitative relationship between HEL-9402 cell transformation and DNAstrand breaks induced by α-particles. Methods Nick translation assay was used to detect the level of DNAstrand break.Cloning formation efficiencies in soft agar were used to evaluate cell transformation. Results Level of DNA strand break and cloning formation efficiencies in soft agar increased obviously after HEL-9402 cells were irradiated by 0.25-5 Gy of α-particles,and there were statistical relationships between DNA strand breaks and cell transformation of irradiated HEL-9402. Conclusion DNAdamages are closely related to α-particle irradiation-induced carcinogenesis. |
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