| LIU Jiamei,CHEN Dong,CHEN Aijun,et al.Studies on induction of apoptosis in mouse Peyer's patches by whole body X-irradiation and its mechanisms[J].Chinese Journal of Radiological Medicine and Protection,2001,21(5):339-341 |
| Studies on induction of apoptosis in mouse Peyer's patches by whole body X-irradiation and its mechanisms |
| Received:November 10, 2000 |
| DOI： |
| KeyWords:X-rays Peyer's patches Apoptosis Bcl-xL Fas-L |
| FundProject:国家教委回国人员科研启动资金;国家自然科学基金资助项目(39570188) |
| Author Name | Affiliation | | LIU Jiamei | Department of Histology &
Embryology, School of Basic Medical Science, Jilin University, Changchun 130021, China | | CHEN Dong | Department of Histology &
Embryology, School of Basic Medical Science, Jilin University, Changchun 130021, China | | CHEN Aijun | Department of Histology &
Embryology, School of Basic Medical Science, Jilin University, Changchun 130021, China | | 刘树铮 | 吉林大学卫生部放射生物学重点实验室 |
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| Abstract:: |
| Objective To study the effect of apoptosis-related genes in mouse Peyer's patches and its molecular mechanism after whole body irradiation(WBI) with different doses of X-rays. Methods Light microscopy and transmission electron microscopy were used to observe the morphology and structure of Peyer's patches and flow cytometry (FCM) was used to detect the changes of Bcl-xL and Fas-Lproteins. Results The apoptosis in Peyer's patches was increased after 2 Gy X-rays and decreased after 75 mGy X-rays.The expression of Bcl-xL protein was decreased and the expression of Fas-Lprotein was increased in Peyer's patches after WBIwith 2 Gy X-rays,whereas the former increased and the latter decreased after WBIwith 75 mGy. Conclusion Apoptosis-related genes such as Bcl-xL,Fas-Lmight play an important role in regulation of radiation-induced apoptosis in Peyer's patches. |
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