| LU Zhe,LIU Shuchun,SUN Zuyue,et al.Time-effect of adaptive response of thymocyte apoptosis and cell cycle progression induced by low dose ionizing radiation in mice[J].Chinese Journal of Radiological Medicine and Protection,2001,21(4):276-278 |
| Time-effect of adaptive response of thymocyte apoptosis and cell cycle progression induced by low dose ionizing radiation in mice |
| Received:September 12, 2000 |
| DOI： |
| KeyWords:Ionizing irradiation Thymocytes Apoptosis Cell cycle progression Adaptive response |
| FundProject:国家自然科学基金资助项目(39170275) |
| Author Name | Affiliation | | LU Zhe | MH Radiobiology Research Unit, Norman Bethune University of Medical Sciences, Changchun 130021, China | | LIU Shuchun | MH Radiobiology Research Unit, Norman Bethune University of Medical Sciences, Changchun 130021, China | | SUN Zuyue | MH Radiobiology Research Unit, Norman Bethune University of Medical Sciences, Changchun 130021, China | | 傅士波 | MH Radiobiology Research Unit, Norman Bethune University of Medical Sciences, Changchun 130021, China | | 龚守良 | MH Radiobiology Research Unit, Norman Bethune University of Medical Sciences, Changchun 130021, China |
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| Abstract:: |
| Objective In the present study we observed the general pattern of the adaptive response of thymocyte apoptosis and cell cycle progression induced by low dose radiation. Methods Kunming male mice were irradiated with the inductive dose(D1,75 mGy)and the challenging dose(D2,1.5 Gy).The intervals between D1 and D2 were 3,6,12,24 and 60 hours separately.The changes of thymocyte apoptosis and cell cycle progression were measured with flow cytometry. Results When the intervals between D1 and D2 were 3,6 and 12 hours,the percentages of apoptotic cells in D1+D2 groups were significantly lower than those in D2 groups (P< 0.05),and the percentages of G0/G1 and G2+M phase cells decreased in varying degrees,while the percentages of S phase cells increased significantly(P<0.05 or P<0.01). Conclusion The results mentioned above indicate that when the mice were irradiated with 75 mGy(D1,12.5 mGy/min)3～12 hours before 1.5 Gy(D2,0.287 Gy/min)exposure,the adaptive response of thymocyte apoptosis and cell cycle progression could be induced under the condition of whole body irradiation. |
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