| GU Guixiong,ZHU Shoupeng,WANG Liuyi.Influence of intracerebral exposure to enriched uranium on neuron specific enolase and interleukin-1 β content in neonatal rats[J].Chinese Journal of Radiological Medicine and Protection,2001,21(4):269-272 |
| Influence of intracerebral exposure to enriched uranium on neuron specific enolase and interleukin-1 β content in neonatal rats |
| Received:October 29, 2000 |
| DOI： |
| KeyWords:Enriched uranium Neonatal rat Brain damage Neuron specific enolase(NSE) Interleukin-1β(IL-1β) |
| FundProject:国家自然科学基金资助项目(39470389) |
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| Abstract:: |
| Objective To examine biochemically the injurious effects of enriched uranium 235U on developing brain of neonatal rats. Methods Neonatal rats were irradiated with single injection of 2 μl enriched uranium into the left lateral ventricle of the brain at postnatal day 1(<24 h)at a dose of 0,1,5,or 10 μg of 235U,respectively.The microautoradiographic tracing was performed,somatic growth and neurobehavior development of neonatal rats were examined by determination of multiple parameters,and the neuron specific enolase(NSE)and interleukin-1β(IL-1β) levels in brains were determined with radioimmunoassay. Results The radionuclides were mainly accumulated in the neuronal nucleus,and autoradiagraphic tracks appeared in the cytoplasm and inter cellular space.Neonatal rats showed delayed growth and abnormal neurobehavior.The changes of NSE,IL-1β in cerebellum,cerebral cortex,hippocampus,diencephalons showed a dose dependent relationship that when the dose of irradiation was increased,the levels of NSE was decreased and the IL-1β was increased. Conclusion The nerve cell of developing brain of neonatal rats issensitive, fragile and compensable to injurious effects of α irradiation from enriched uranium. |
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