| LIU Yulong,ZHOU Jianying,WANG Guoquan.Experimental study of radioprotective effects of rhIL-8 on irradiated mice and its mechanism[J].Chinese Journal of Radiological Medicine and Protection,2001,21(4):241-243 |
| Experimental study of radioprotective effects of rhIL-8 on irradiated mice and its mechanism |
| Received:April 30, 2001 |
| DOI： |
| KeyWords:Interleukin-8 BALB/c mouse Radiation injury |
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| Author Name | Affiliation | | LIU Yulong | No. 2 Hospital Attached to Suzhou University, Suzhou 215004, China | | ZHOU Jianying | No. 2 Hospital Attached to Suzhou University, Suzhou 215004, China | | WANG Guoquan | No. 2 Hospital Attached to Suzhou University, Suzhou 215004, China | | 戴宏 | No. 2 Hospital Attached to Suzhou University, Suzhou 215004, China | | 段莹莹 | No. 2 Hospital Attached to Suzhou University, Suzhou 215004, China | | 郭晓葵 | No. 2 Hospital Attached to Suzhou University, Suzhou 215004, China | | 李元 | No. 2 Hospital Attached to Suzhou University, Suzhou 215004, China |
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| Abstract:: |
| Objective To study the radioprotective effects of rhIL-8 on irradiated mice and its mechanism. Methods Single intraperitoneal injections of rhIL-8 at 10 μg or 30 μg at different times to BALB/c mice before they were exposed to 8.5 Gy or 6.5 Gy 6 MV X-rays.The survival state of mice and some monitoring indices were observed. Results The survival times of irradiated mice were closely related to the dose lever of rhIL-8 and the injection time.CFU-GM counts of bone marrow cells,serum total contents of superoxide dismutase (T-SOD) and malondialdehyde (MDA),and immunity function indices were examined in all mice at six days after expousure 6.5 Gy 6 MV X-rays.It is showed that the examination findings and the survival state of irradiated mice were interrelated with one another. Conclusion rhIL-8 has certain radioprotective effects through complex mechanisms of modulation of hematopoiesis, immuno-modulation,clearance of free radicals,etc. |
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